It is used to prevents the seasonal and perennial allergic rhinitis, allergic dermatitis, idiopathic urticaria and ocular allergy. Loratadine (LOR, Figure 1) is a second-generation nonsedative tricyclic antihistaminic (H1) drug. The aqueous solubility of drug molecules is a major challenge and critical step to achieve an optimal bioavailability after oral administration of its pharmaceutical dosage form. Loratadine Glycerin Nanoparticles Precipitation method Hydrogel IntroductionĪn approximately 65% of the human body is made up of water, therefore drug molecules must have certain aqueous solubility to achieve an acceptable bioavailability level. The developed method could be used for different insoluble candidates. The obtained results showed that LOR-GNPs are considered a new addition for improvement of LOR solubility when applied as a hydrogel. The results proved that the GNPs penetrated abdominal rat skin. The hydrogel showed accepted viscosity, spreadability, and homogeneity. LOR-GNPs were formulated as a hydrogel to check their suitability for a dosage form usage. The EE% free LOR was found to be satisfactory with a mean content of 98.1 ± 0.3 and a relative standard deviation below 2.0% indicates the reproducibility of the LOR release. The hydrogel viscosity, spreadability, homogeneity and abdominal rat skin permeation were studied and optimized DLS indicated a successful coating of LOR with glycerin surface that recorded an average size of 334 ± 30 nm with uniform particle size, while SEM showed LOR-NPs in different shapes. Furthermore, the GNPs were formulated in hydrogel. LOR-GNPs were prepared by a precipitation method and then evaluated for such size and morphology using dynamic scattering spectroscopy (DLS) and scanning electron microscopy (SEM), as well as the percentage entrapment efficiency (EE%) of free LOR from GNPs formulations was performed using titration method. The aim of this work is to formulate novel LOR-glycerin nanoparticles (LOR-GNPs) to increase LOR bioavailability. Owing to its slightly aqueous solubility, loratadine (LOR) is used in high doses in different marketed formulations to achieve its desirable bioavailability.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |